Because of this activity it is a safe and potent ingredient for use in skin anti aging and anti wrinkles cosmetics. Metabolite profiling and woundhealing activity of boerhavia. There was a significant delay in the onset of convulsions and reduction in mortality at all the three doses of crude extract fraction 1, 1500 and 2000 mg k in ptz model, as compared with vehicle control. Phytochemical and in vitro antidiabetic activity of. In order to determine the in vitro anti diabetic activity, amylase inhibition studies and glucose diffusion inhibition studies were carried out. Medicinal plants have been used from the beginning of human civilization, which is mostly evident from the ancient script and traditional herbal medicine recipe. Hplc results showed that the concentration of phytoconstituents showed a negative correlation with the ploidy level being maximum in plants with lower ploidy levels. Gopal tk, harish g, chamundeeswari d, umamaheswara reddy c. The plant is named after of hermann boerhaave, a famous dutch physician of the 18th century1. Boerhaavia diffusa inhibits key enzymes linked to type 2. Medicinal plants with anti diabetic activity gymnema sylvestre gymnema sylvestre gs is one of the important medicinal herb and possess anti hyperglycemic activity, often used to supplement patients having dm 8.
In that case also the nature of soil was the main responsible factor. Physical and phytochemical screening of boerhaavia diffusa. Subchronic toxicity studies of the aqueous extract of boerhavia diffusa leaves. Boerhavia diffusa is originated throughout the warmer parts of the country upto an altitude of 2000 metre in the himalayan region. Introduction historically, plants have provided a source of inspiration for novel drug compounds, as plant derived medicines have made large contributions to human health and wellbeing. Hyperlipidemia is an associated complication of diabetes mellitus. Potential antidiabetic activity of medicinal plants a. Detail study on boerhaavia diffusa plant for its medicinal. The worldwide use of boerhavia diffusa roots was validated when researchers demonstrated in the year 1980 and 1991 anti hepatotoxic properties in the root extract15, 16. Hepatoprotective activity of boerhavia diffusa extract. Anti diabetic property indigenous system of medicine in india has recommended many herbal medicines including b. The preliminary phytochemical screening tests for the methanol extract of psidium guajava leaves table 1 revealed the presence of carbohydrates, alkaloids, flavones, tannins, steroidal glycosides, phenols and coumarin. Jan 01, 2019 anti diabetic activity of smk001, a poly herbal formula in streptozotocin induced diabetic rats.
The herb gs cultivated in southern region asia and the east indies. Over the last decade, along with the effort of moonshot sm project, local scientists from different parts of the work tried to curate the information of traditional herbal practice, preparation, recipe, and their ailments 12, 9597. Phytochemical and biological importance of boerhavia. Some of the promising effects of this plant include diuretic, hepatoprotective, anti inflammatory, anti fibrinolytic, anti cancer, anti diabetic, immunomodulatory, immunosuppressive, anti. Cronicon open access ec pharmacology and toxicology research. Based on the wound healing and anti diarrheal activity present study was carried out to evaluate both anti bacterial and antifungal activity of aforementioned plant 6,7. The study indicates that boerhaavia diffusa and ethanolic. Invitro anti oxidant activity of roots of boerhaavia diffusa linn. Phytochemical, therapeutic, and ethnopharmacolgical overview for a.
Antidiabetic and antioxidants activity of boerhavia diffusa l. Phytochemical screening and in vitro bioactivities of the extracts of. Molecular taxonomic identification, biosynthesis and in vitro. This plant has gained lot of importance in the field of phytochemistry because of its various pharmacological and biological activities 8. Boerhavia diffusa, phytochemicals, proximate analysis, sulphated ash, antinutrients 1. Despite the historically enriched demonstration about the use of plant as therapeutics, the pharmaceutical industries lack interest on phytochemical research compared with synthetic drug. This plant commonly known as punarnava, is herb of family nyctaginaceae. Boerhavia diffusa is a tropical creeping root herb, with bioactive compounds in both the leaves and roots. Several researchers have confirmed biological, pharmacological and clinical activities of the plant and its phyto constituents. Based on the wound healing and anti diarrheal activity present study was carried out to evaluate both anti bacterial and antifungal activity. This study tries to discover a novel potential inhibitor to the main protease of the virus, by computer aided drug discovery where various major active phytochemicals of the plant boerhavia diffusa linn. Pharmacological activities anti bacterial activity. Morphological and cytogenetic analysis of different cytotypes. The phytochemical investigation showed the presence of carbohydrates, alkaloid, protein, terpenoid and flavanoid in both aqueous and alcoholic extract.
After irradiation, there was no fall in rbc count and hb unlike in controls. Battery of phytochemicals like alkaloids, flavonoids, rotenoids and. Phytochemical analysis of extracts prepared from b. Boerhavia diffusa nyctaginaceae is known as punarnava and is used as diuretic, hepatoprotective and for treatment of other diseases in the indian medicinal system. Methods experimental diabetes was induced in wistar albino rats by administering single dose of stz 40 mgkg. Antimicrobial activity study of ethanolic extract of. Diabetes mellitus is a group of metabolic alterations characterized by hyperglycemia resulting from defects in insulin secretion, action or both. Any of these secondary metabolites, singly or in combination with others could be responsible for the anti diabetic activity of. Tea is easy to use also, good in taste and even on high use it is nontoxic. Root extract via free radical scavenging and antioxidant mechanism anti diabetic effect of boerhavia diffusa l. Evaluation of phytochemical and antimicrobial activities of boerhavia diffusa. Phytochemical and biological importance of boerhavia diffusa.
Effect of chronic administration of boerhaavia diffusa linn. Jan 01, 2020 it is an abundantly growing perennial creeping herb, found throughout india. Boerhavia diffusa, rotenoids, hsccc, biological activity. Apart from having anti diabetic activity, this plant also has anti bacterial, antimalarial, antifertility, hepatoprotective and antioxidant effects. Tea is easy to use also, good in taste and even on high use it. The present study was designed to investigate the antihyperlipidemic activity of an aqueous extract of boerhavia diffusa leaves in alloxan diabetic rats. Anti diabetes and anti obesity medicinal plants and phytochemicals. A study was carried out to investigate the effects of daily oral. The gs plant root and leaves possess medicinal value but.
Phytochemical, therapeutic, and ethnopharmacological overview. Review article pharmacological properties of boerhaavia. Other importa department of biotechnology and genetic engineering, faculty of applied science and technology, islamic university, kushtia7003, bangladesh. Antidiabetic action of the extract was attributed to its role in rejuvenation of pancreatic. Boerhavia diffusa and andrographis paniculata species have been of keen interest in phytochemical and pharmacological research due to their excellent medicinal values. It is not surprising that there are differences in the antimicrobial effects of different solvent extracts due to the phytochemical properties and differences among species. In this context, we intended to assess the phytochemical makeup of two ethnopharmacologically important herbal plants. Boerhavia diffusa bd is a plant of rasayana category as per ayurvedic claims.
Feb 18, 2021 various phytochemical, pharmacological, experimental and clinical investigations are done on boerhaavia diffusa by many scientist, researchers etc. Boerhavia diffusa, bioactive phytochemicals, pharmacological properties, hepatoprotective introduction boerhavia diffusa, a perennial herb with stout root stock and many procumbent branches, flowers pale rose coloured, small, shortstalked. Boerhaavia diffusa, belonging to nyctaginaceae family, also known as punarnava. There was a significant delay in the onset of convulsions and reduction in mortality at all the three doses of crude extract fraction 1, 1500 and 2000 mg k in ptz model, as compared with vehicle control group. Pdf antidiabetic effect of boerhavia toxicology and. Diabetic cataract and role of antiglycating phytochemicals. The main aim of the present study was to evaluate the hepatoprotective activity of boerhavia diffusa extract against ccl4induced hepatotoxicity in swiss. Antioxidant activity the methanol extract of the leaves, stem, and the root of boerhavia diffusa was estimated for total antioxidant capacity using 1, 1diphenyl picrylhydrazyl dpph free radical scavenging assay, total. Physical and phytochemical screening of boerhaavia diffusa l. It is a perennial, spreading hogweed, commonly grown abundantly in waste places, ditches. Ayurveda is a native indian healthcare system which is currently used by millions of people in india, nepal and sri lanka for their daytoday healthcare needs.
Various phytochemical, pharmacological, experimental and clinical investigations are done on boerhaavia diffusa by many scientist, researchers etc. The invention relates to the use of a purified boerhavia diffusa extract that is rich in hydroxybenzoic compounds, as an active ingredient in the preparation of a cosmetic composition for skin relief and for increasing skin comfort. Nyctaginaceae methanolic extract have been investigated against phytophthora infestans and phytophthora capsici, causal agents of late blight disease in tomato and pepper, respectively. Nyctaginaceae, commonly known as punarnava in sanskrit, is a creeping weed found abundantly all over india. The objective of this work was to evaluate the antidiabetic activity of such herbal extracts of roots of withania somnifera, boerhaavia diffusa, and their combination in experimentally induced diabetic rats. Pdf nutritive and antinutritive analysis in boerhavia. Safety efficacy and action mechanisms pdf author bashar saad isbn b072fcnpvk file size 5.
The aqueous extracts of boerhavia diffusa roots are a rich source of basic protein known as systemic resistance inducing protein bd. Traditional healers have been patronizing various species of this genus in numerous disorders since time immemorial. The two plant extracts and their combination at a dose of 200 mgkgday were administered to dexamethasoneinduced insulinresistant animals for 10 consecutive days. Antidiabetic activity of boerhaavia diffusa l effect on hepatic key enzymes in. Potential antidiabetic activity of medicinal plants a short. Molecular taxonomic identification, biosynthesis and in.
Boerhavia diffusa an overview sciencedirect topics. Wo2009044040a1 use of boerhavia diffusa extract for skin. Determination of the phytochemical constituents of these extracts was then carried out by employing standard procedures. Boerhaavia diffusa l, angle of repose, extractive values. Mishra s, aeri v, gaur pk, jachak sm 2014 phytochemical, therapeutic and ethanopharmacological overview for a traditionally important herbs. The two plant extracts and their combination at a dose of 200 mgkgday were administered to dexamethasoneinduced insulin. Research journal of pharmaceutical, biological and chemical sciences. Phytochemical investigation of boerhavia diffusa and. Morphological and cytogenetic analysis of different. Anti oxidant activity was determined using the dpph method. Many herbs and spices are known to be antihyperglycemic. The genus boerhavia nyctaginaceae consists of 40 species that are distributed in humid, subtropical and warm climate regions.
Venkatalakshmi p, eazhisai vd, netaji s 2011 hepatoprotective activity of boerhavia diffusa against paracetamol induced toxicity in rats. Pdf detail study on boerhaavia diffusa plant for its. Santhosha d, ramesh a, sravan prasad m, sathis kumar d, pawan kumar b, dhanalakshmi ch. Antioxidant activity the methanol extract of the leaves, stem, and the root of boerhavia diffusa was estimated for total antioxidant capacity using 1, 1diphenyl picrylhydrazyl dpph free radical scavenging assay, total phenolic, flavonoid and ascorbic acid contents. The presence of these constituents is responsible for the wide medicinal use of boerhaavia diffusa l. Studies are in progress in the laboratory to unveil the active components responsible for the bioactivities. Both plants are well known for their potential medicinal activities. Hepatotoxicity and the role of some herbal hepatoprotective.
As this activity retained only in liriodendrinrich fraction, this confirms that the anti convulsant activity of the crude methanolic extract is due to the presence of liriodendrin. In addition different solvent extractof this plant proved to have different pharmacological activities viz. Type i diabetes often referred to as juvenile diabetes, is insulin dependent and known to affect only 5% of the diabetic population. It was discovered that multiple constituents are usually responsible for the. Oct 17, 2018 objective the present study was proposed to assess the in vitro free radicalscavenging activity of b. Furthermore, to find out the target of potential phytochemicals is easier than ever, because of advancement of genomics, proteomics, transcriptomics, and. A boerhavia coccinea, b boerhavia elegans, c boerhavia erecta, d boerhavia repens, e boerhavia diffusa. Phytochemical screening and in vitro bioactivities of the. One week later rats with blood glucose level 200 mgdl. Phytochemical assessment and metabolic fingerprinting of boerhavia diffusa and cephalandra indica from indian subcontinent html full text. The findings of the present study suggested that the methanolic extract of b. Such plants have demonstrated promising anti cancer, anti viral, anti inflammatory and anti oxidant agents due to the presence of compounds and secondary metabolites which are biologically active. Oct 15, 2016 antifungal properties of boerhavia diffusa l.
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